Monday, December 03, 2007


Avandia, Implicated in Osteoporosis and Rheumatoid Arthritis


Avandia, a medicine that is used to boost the effects of insulin for type 2 diabetics, may be increasing the risk of brittle bone disease by interfering with new bone formation. See the article at:



Avandia contains:
hypromellose
lactose monohydrate
magnesium stearate
microcrystalline cellulose
Opadry orange OY-L-23028
glycerol triacetate
hypromellose 6cP r
iron oxide red E172
iron oxide yellow E172
lactose monohydrate
macrogol 3000
purified talc
titanium dioxide (E171)
rosiglitazone maleate
sodium starch glycollate (type A) ( http://medguides.medicines.org.uk/document.aspx?name=Avandia&use=diabetes&section=ingredients )


The study says that mice were used as the subjects. What I still want to know is this:


1. What is the incidence of osteoporosis and patients with diabetes who take Avandia and What is the incidence of osteoporosis and patients with diabetes who do not take Avandia.


2. What is the incidence of osteoporosis and patients with diabetes who take Avandia and who also have gluten intolerance and those who do not)


3. What is the source of microcrystalline cellulose.


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Of course I am wondering because of my own personal experience with Actonel, which basically prevented me from absorbing food for about 2 days out of 7, which contains


Resedronate Sodium

Crospovidone

ferric oxide red (35 mg and 75 mg tablets only)

ferric oxide yellow (5 mg and 35 mg tablets only)

hydroxypropyl cellulose

hydroxypropyl methylcellulose

lactose monohydrate (5 mg, 30 mg and 35 mg tablets only)

magnesium stearate

microcrystalline cellulose

polyethylene glycol

silicon dioxide

titanium dioxide


By the way, I contacted the local gluten free society to let them know that Actonel contained cellulose (which may be derived from wheat straw) and they politely told me that they believed that Actonel did not contain gluten.


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So the other thing I am wondering is where does that cellulose come from? I did a small search on this before and was unable to show a definitive link to wheat. I just saw one reference to it coming from wheat straw.


I am also wondering what other medications contain cellulose and if there is an increased incidence of osteoporosis in any other groups.


There is a magazine: I can check it out:


Possibly the editor of the journal could help me find the information.
Well, dear reader (myself). This is a little unorganized, but at least my concerns are posted.